Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 4/20 | 0.63 |
| ▸ | PGR | P06401 | 3/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.45 |
| ▸ | PRF1 | P14222 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031985 | 0.86 | GRM5 (0.62) | HSD17B1PGRGRM5CYP11B1CYP11B2 | |
| SCHEMBL29741348 | 0.86 | GRM5 (0.62) | HSD17B1PGRGRM5CYP11B1CYP11B2 | |
| SCHEMBL4423216 | 0.86 | PGR (0.56) | HSD17B1PGRHRH3GRM5CYP1A2 | |
| SCHEMBL28655414 | 0.84 | HSD17B1 (0.78) | HSD17B1PGRHRH3GRM5CYP1A2 | |
| SCHEMBL385683 | 0.80 | MAOB (0.59) | PGRHRH3GRM5MAOAMAOB | |
| SCHEMBL1745161 | 0.79 | HSD17B1 (0.71) | HSD17B1PGRHRH3GRM5CYP1A2 | |
| SCHEMBL1030949 | 0.77 | HSD17B1 (1.00) | HSD17B1PGRGRM5CYP1A2CYP11B1 | |
| SCHEMBL1747435 | 0.77 | HSD17B1 (0.69) | HSD17B1PGRGRM5CYP1A2CYP11B1 | |
| SCHEMBL1746656 | 0.77 | HSD17B1 (0.69) | HSD17B1PGRGRM5CYP1A2CYP11B1 | |
| SCHEMBL1745120 | 0.77 | HSD17B1 (0.69) | HSD17B1PGRHRH3GRM5CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325916-A1 | 5-ARYL INDAN-1-ONE AND ANALOGS USEFUL AS PROGESTERONE RECEPTOR MODULATORS | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
| US-20080119537-A1 | 5-Aryl indan-1 one and analogs useful as progesterone receptor modulators | WYETH (US) | 2008-05-22 | — | — | US | disclosed |
| US-7319152-B2 | Contraception, hormone replacement therapy, cycle-related symptoms, or benign or malignant neoplastic disease; -methyl-5-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrrole-2-carbonitrile | WYETH (US) | 2008-01-15 | — | — | US | disclosed |
| US-20070066628-A1 | 5-Aryl-indan-1-ol and analogs useful as progesterone receptor modulators | WYETH (US) | 2007-03-22 | — | — | US | disclosed |
| US-20070066675-A1 | 5-Aryl-indan-1-one and analogs useful as progesterone receptor modulators | WYETH (US) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066628-A1 | 5-Aryl-indan-1-ol and analogs useful as progesterone receptor modulators | PGR, CYP19A1, GNRHR | HSD17B1 113/4885PGR 1/4885HRH3 574/4885 |
| US-20070066675-A1 | 5-Aryl-indan-1-one and analogs useful as progesterone receptor modulators | PGR, CYP19A1, GNRHR | HSD17B1 146/4885PGR 1/4885HRH3 532/4885 |
| US-20090325916-A1 | 5-ARYL INDAN-1-ONE AND ANALOGS USEFUL AS PROGESTERONE RECEPTOR MODULATORS | CYP19A1, PGR, NR5A1 | HSD17B1 58/4885PGR 2/4885HRH3 1705/4885 |
| US-20080119537-A1 | 5-Aryl indan-1 one and analogs useful as progesterone receptor modulators | CYP19A1, PGR, NR5A1 | HSD17B1 64/4885PGR 2/4885HRH3 1756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.