Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.57 |
| ▸ | PPARD | Q03181 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64148 | 0.89 | KMT2A (0.54) | ABCB1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL63188 | 0.85 | NPC1 (0.52) | ABCB1MEN1KMT2AFGFR1FGFR2 | |
| SCHEMBL63678 | 0.84 | HDAC1 (0.48) | ABCB1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL62401 | 0.84 | NR3C2 (0.48) | ABCB1KMT2ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL4553730 | 0.83 | ABCB1 (0.45) | ABCB1MEN1KMT2AFGFR1FGFR2 | |
| SCHEMBL63175 | 0.83 | KDM4E (0.47) | ABCB1MEN1KMT2AABCG2SMN1; SMN2 | |
| SCHEMBL4440100 | 0.82 | RAB9A (0.53) | ABCB1PPARDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL64844 | 0.82 | CA1 (0.51) | ABCB1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL64290 | 0.82 | RAB9A (0.62) | ABCB1MEN1KMT2ASMN1; SMN2KDM4E | |
| Benzoyl Chloride SCHEMBL4435271 | 0.81 | NPC1 (0.48) | ABCB1MEN1KMT2AFGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |