Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 5/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64290 | 0.92 | RAB9A (0.62) | RAB9AABCB1ADORA2AEGLN2NR3C2 | |
| SCHEMBL62401 | 0.85 | NR3C2 (0.48) | RAB9AABCB1NR3C2PLAUSMN1; SMN2 | |
| SCHEMBL4553730 | 0.84 | ABCB1 (0.45) | RAB9AABCB1NR3C2KDM4ESMN1; SMN2 | |
| SCHEMBL4430176 | 0.82 | ABCB1 (0.57) | RAB9AABCB1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL64148 | 0.80 | KMT2A (0.54) | RAB9AABCB1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL63678 | 0.80 | HDAC1 (0.48) | RAB9AABCB1NR3C2KDM4ESMN1; SMN2 | |
| SCHEMBL64374 | 0.80 | RAB9A (0.46) | RAB9AABCB1NR3C2SMN1; SMN2 | |
| SCHEMBL63175 | 0.78 | KDM4E (0.47) | RAB9AABCB1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL64844 | 0.78 | CA1 (0.51) | RAB9AABCB1ADORA2ASMN1; SMN2NPC1 | |
| SCHEMBL62684 | 0.76 | LMNA (0.46) | RAB9AABCB1KDM4ESMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |