Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | F10 | P00742 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL918622 | 0.79 | NOTUM (0.54) | NOTUMF10ALDH1A1AKR1C3MAPT | |
| SCHEMBL2073478 | 0.77 | NOTUM (0.81) | NOTUMALDH1A1AKR1C3MAPTKMT2A | |
| SCHEMBL11051087 | 0.77 | HRH3 (0.57) | ALDH1A1AKR1C3MAPTKMT2AMEN1 | |
| SCHEMBL10013762 | 0.77 | HSD17B1 (0.51) | ALDH1A1KDM4EACKR3MAPT | |
| SCHEMBL18395565 | 0.75 | NOTUM (0.64) | NOTUMALDH1A1AKR1C3MAPTMAPK1 | |
| SCHEMBL25262380 | 0.75 | MAPT (0.66) | NOTUMALDH1A1KDM4EAKR1C3MAPT | |
| SCHEMBL4558490 | 0.73 | HTT (0.55) | NOTUMALDH1A1KMT2AMEN1PKM | |
| SCHEMBL9081654 | 0.72 | CYP46A1 (0.59) | NOTUMALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL4476298 | 0.72 | RORC (0.54) | NOTUMALDH1A1KDM4EMAPTMAPK1 | |
| SCHEMBL2158833 | 0.72 | NOTUM (0.54) | NOTUMALDH1A1AKR1C3MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049120-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008016534-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-02-07 | — | — | WO | disclosed |