Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GRM8 | O00222 | 1/20 | 0.35 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
| ▸ | GABRD | O14764 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441504 | 0.84 | CYP3A4 (0.31) | — | |
| SCHEMBL4436006 | 0.81 | CYP2C19 (0.54) | CYP2C19CYP1A2ALOX15GABRPGABRD | |
| SCHEMBL8004566 | 0.75 | CYP2C19 (0.52) | CYP2C19ITGB3ITGA2BGRM2GRM3 | |
| SCHEMBL848416 | 0.73 | CYP2C19 (0.50) | CYP2C19ITGB3ITGA2BGRM2GRM3 | |
| SCHEMBL8810863 | 0.69 | CYP2C19 (0.46) | CYP2C19ITGB3ITGA2BGRM2GRM3 | |
| SCHEMBL4532840 | 0.69 | CYP2C19 (0.46) | CYP2C19ITGB3ITGA2BGRM2GRM3 | |
| SCHEMBL515587 | 0.67 | CYP2C19 (0.44) | CYP2C19ITGB3ITGA2BGRM2GRM3 | |
| SCHEMBL11646566 | 0.66 | CYP2C19 (0.62) | CYP2C19ITGB3ITGA2BGRM2GRM3 | |
| SCHEMBL23603993 | 0.66 | CYP2C19 (0.42) | CYP2C19ITGB3ITGA2BGRM2GRM3 | |
| Hydrochloric Acid SCHEMBL11636408 | 0.66 | CYP2C19 (0.42) | CYP2C19ITGB3ITGA2BGRM2GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124944-A1 | PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | Ranbaxy Laboratories Limited (IN) | 2009-12-02 | — | — | EP | claimed |
| WO-2008111010-A1 | PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2008-09-18 | — | — | WO | claimed |