Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.42 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GRM8 | O00222 | 1/20 | 0.42 |
| ▸ | GRM6 | O15303 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11636408 | 0.98 | CYP2C19 (0.42) | CYP2C19GRM2GRM3GRM4TSHR | |
| SCHEMBL8810863 | 0.98 | CYP2C19 (0.46) | CYP2C19GRM2GRM3GRM4TSHR | |
| SCHEMBL4532840 | 0.93 | CYP2C19 (0.46) | CYP2C19GRM2GRM3GRM4TSHR | |
| SCHEMBL8004566 | 0.90 | CYP2C19 (0.52) | CYP2C19GRM2GRM3GRM4TSHR | |
| SCHEMBL848416 | 0.87 | CYP2C19 (0.50) | CYP2C19GRM2GRM3GRM4TSHR | |
| SCHEMBL4072778 | 0.86 | CYP2C19 (0.52) | CYP2C19GRM2GRM3GRM4TSHR | |
| SCHEMBL3021254 | 0.84 | CYP2C19 (0.54) | CYP2C19GRM2GRM3GRM4TSHR | |
| SCHEMBL23603993 | 0.79 | CYP2C19 (0.42) | CYP2C19GRM2GRM3GRM4TSHR | |
| SCHEMBL10019498 | 0.79 | GRM5 (0.39) | GRM5ITGB3ITGA2B | |
| SCHEMBL7692038 | 0.79 | GRM5 (0.39) | GRM5ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107687-A1 | INHIBITORS OF MENIN-MLL INTERACTION | BALA THERAPEUTICS, INC. (US) | 2023-06-15 | — | — | WO | disclosed |
| WO-2022223033-A1 | SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| WO-2022223034-A1 | SOS1 DEGRADATION AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| US-9453005-B2 | Inhibition of influenza M2 proton channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-09-27 | — | — | US | disclosed |
| US-9453005-B2 | Inhibition of influenza M2 proton channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-09-27 | — | — | US | disclosed |
| US-9403839-B2 | Pyran-spirocyclic piperidine amides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-08-02 | — | — | US | disclosed |
| US-9403777-B2 | Inhibitors of the influenza A virus M2 proton channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-08-02 | — | — | US | disclosed |
| US-9403777-B2 | Inhibitors of the influenza A virus M2 proton channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-08-02 | — | — | US | disclosed |
| US-9403777-B2 | Inhibitors of the influenza A virus M2 proton channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-08-02 | — | — | US | disclosed |
| EP-2520568-B1 | Spirocyclic nitriles as inhibitors of protease | SANOFI SA (FR) | 2015-09-09 | — | — | EP | disclosed |
| US-20120015933-A1 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2012-01-19 | — | — | US | disclosed |
| US-20110288111-A1 | INHIBITION OF INFLUENZA M2 PROTON CHANNEL | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110288111-A1 | INHIBITION OF INFLUENZA M2 PROTON CHANNEL | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-11-24 | — | — | US | disclosed |
| US-8039480-B2 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2011-10-18 | — | — | US | disclosed |
| US-8039480-B2 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2011-10-18 | — | — | US | disclosed |
| WO-2010033339-A1 | INHIBITION OF INFLUENZA M2 PROTON CHANNEL | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-03-25 | — | — | WO | disclosed |
| US-20090275523-A1 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2009-11-05 | — | — | US | disclosed |
| US-20090275523-A1 | Spirocyclic nitriles as protease inhibitors | SANOFI-AVENTIS (FR) | 2009-11-05 | — | — | US | disclosed |
| WO-2007137738-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-12-06 | — | — | WO | disclosed |
| US-4098823-A | VASODILATION, HYPOTENSIVE AGENTS, ANTICOAGULATNS, ANTISECRETORY AGENTS, INOTROPIC AGENTS | MILES LABORATORIES, INC. (US) | 1978-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275523-A1 | Spirocyclic nitriles as protease inhibitors | CTRL, SERPINB1, PREP | CYP2C19 510/4885GRM2 4340/4885GRM3 4315/4885 |
| US-20120015933-A1 | Spirocyclic nitriles as protease inhibitors | CTRL, SERPINB1, PREP | CYP2C19 510/4885GRM2 4340/4885GRM3 4315/4885 |
| US-20110288111-A1 | INHIBITION OF INFLUENZA M2 PROTON CHANNEL | HVCN1, TRPM2, ASIC1 | CYP2C19 2489/4885GRM2 536/4885GRM3 1026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.