Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 17/20 | 0.53 |
| ▸ | EGLN2 | Q96KS0 | 6/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 6/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5309258 | 0.87 | EGLN1 (0.49) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL5309053 | 0.77 | EGLN1 (0.41) | EGLN1EGLN2EGLN3SERPINE1 | |
| SCHEMBL5312400 | 0.76 | MEN1 (0.48) | EGLN1EGLN3 | |
| SCHEMBL5311709 | 0.76 | EGLN1 (0.43) | EGLN1EGLN2EGLN3 | |
| SCHEMBL5306234 | 0.76 | TDP1 (0.45) | EGLN1EGLN2EGLN3 | |
| SCHEMBL5305537 | 0.76 | TDP1 (0.45) | EGLN1 | |
| SCHEMBL5309396 | 0.75 | EGLN1 (0.43) | EGLN1EGLN3 | |
| SCHEMBL5312251 | 0.74 | MEN1 (0.48) | EGLN1EGLN3 | |
| SCHEMBL3515037 | 0.73 | EGLN1 (0.70) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL5308968 | 0.72 | MEN1 (0.49) | EGLN1SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136810-A1 | NOVEL 1,8-NAPHTHYRIDINE COMPOUNDS | Merck & Co., Inc. (US) | 2009-12-30 | — | — | EP | claimed |
| WO-2008130527-A1 | NOVEL 1,8-NAPHTHYRIDINE COMPOUNDS | MERCK & CO., INC. (US) | 2008-10-30 | — | — | WO | claimed |