⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15012968 | 1.00 | — | — | |
| SCHEMBL13471058 | 1.00 | — | — | |
| SCHEMBL27710968 | 0.93 | — | — | |
| SCHEMBL27711946 | 0.84 | — | — | |
| SCHEMBL2779428 | 0.75 | — | — | |
| SCHEMBL15744233 | 0.74 | — | — | |
| SCHEMBL13398291 | 0.72 | DPP4 (0.32) | — | |
| SCHEMBL17308616 | 0.71 | — | — | |
| SCHEMBL27653294 | 0.71 | — | — | |
| SCHEMBL10814989 | 0.71 | LMNA (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924275-A4 | THIO-CONTAINING INHIBITORS OF AMINOPEPTIDASE P, COMPOSITIONS THEREOF AND METHOD OF USE | SIMMONS WILLIAM H (US) | 2009-07-29 | — | — | EP | claimed |
| EP-1924275-A2 | THIO-CONTAINING INHIBITORS OF AMINOPEPTIDASE P, COMPOSITIONS THEREOF AND METHOD OF USE | Simmons, William H. (US) | 2008-05-28 | — | — | EP | claimed |
| WO-2007032887-A2 | THIO-CONTAINING INHIBITORS OF AMINOPEPTIDASE P, COMPOSITIONS THEREOF AND METHOD OF USE | SIMMONS WILLIAM H (US) | 2007-03-22 | — | — | WO | claimed |
| CN-108431008-A | It can be used for treating the compound and composition with the relevant illnesss of NTRK | 蓝图药品公司 | 2018-08-21 | — | — | CN | disclosed |
| CN-107949562-A | The positive allosteric modulators of muscarinic M2 acceptors | 拜耳制药股份公司 | 2018-04-20 | — | — | CN | disclosed |
| CN-106164068-A | Isoindolinone compounds as the GPR119 regulator for the treatment of diabetes, obesity, dyslipidemia and associated conditions | 赛诺菲 | 2016-11-23 | — | — | CN | disclosed |
| EP-1924275-A4 | THIO-CONTAINING INHIBITORS OF AMINOPEPTIDASE P, COMPOSITIONS THEREOF AND METHOD OF USE | SIMMONS WILLIAM H (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1924275-A2 | THIO-CONTAINING INHIBITORS OF AMINOPEPTIDASE P, COMPOSITIONS THEREOF AND METHOD OF USE | Simmons, William H. (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007032887-A2 | THIO-CONTAINING INHIBITORS OF AMINOPEPTIDASE P, COMPOSITIONS THEREOF AND METHOD OF USE | SIMMONS WILLIAM H (US) | 2007-03-22 | — | — | WO | disclosed |
| CN-1113064-C | Cis-substituted aminocyclopropane derivatives | DAIICHI SEIYAKU CO (JP) | 2003-07-02 | — | — | CN | disclosed |
| CN-1228776-A | Cis-substituted aminocyclopropane derivatives | DAIICHI SEIYAKU CO (JP) | 1999-09-15 | — | — | CN | disclosed |
| CN-1190954-A | Process for the preparation of (thio-) carbonic/carbamic acid 2-pyrrolidonyl-3-esters, thio esters and amides | ZENECA LTD (GB) | 1998-08-19 | — | — | CN | disclosed |