Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 4/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441647 | 0.94 | KDM4E (0.42) | KDM4ECCR2CASRTACR1ALDH1A1 | |
| SCHEMBL4428140 | 0.90 | CTSA (0.37) | CTSACNR1CNR2CASRUTS2R | |
| SCHEMBL4431321 | 0.90 | CTSA (0.37) | CTSACNR1CNR2CASRUTS2R | |
| SCHEMBL4427927 | 0.84 | CNR1 (0.51) | KDM4ECNR1CNR2CCR2CASR | |
| SCHEMBL4434552 | 0.84 | CNR1 (0.51) | KDM4ECNR1CNR2CCR2CASR | |
| SCHEMBL4441795 | 0.82 | KDM4E (0.46) | KDM4ECNR1CNR2CCR2TACR1 | |
| SCHEMBL4430647 | 0.82 | KDM4E (0.46) | KDM4ECNR1CNR2CCR2TACR1 | |
| SCHEMBL4431479 | 0.82 | ALOX5 (0.39) | CNR2CCR2CASRTACR1ALOX5 | |
| SCHEMBL4432382 | 0.82 | ALOX5 (0.39) | CNR2CCR2CASRTACR1ALOX5 | |
| SCHEMBL4441777 | 0.81 | KDM4E (0.46) | KDM4ECCR2TACR1ALDH1A1CTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |