Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HAT1 | O14929 | 2/20 | 0.37 |
| ▸ | EP300 | Q09472 | 2/20 | 0.37 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4431479 | 1.00 | ALOX5 (0.39) | ALOX5EPHX2SLC7A5CASRSLC6A2 | |
| SCHEMBL4431321 | 0.92 | CTSA (0.37) | ALOX5EPHX2CASRCNR2 | |
| SCHEMBL4428140 | 0.92 | CTSA (0.37) | ALOX5EPHX2CASRCNR2 | |
| SCHEMBL4441647 | 0.89 | KDM4E (0.42) | ALOX5EPHX2CASRTACR1TACR3 | |
| SCHEMBL4434660 | 0.86 | ALOX5 (0.43) | ALOX5EPHX2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4427996 | 0.86 | ALOX5 (0.43) | ALOX5EPHX2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4432348 | 0.84 | FFAR1 (0.40) | ALOX5EPHX2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4432136 | 0.84 | FFAR1 (0.40) | ALOX5EPHX2SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL4434483 | 0.83 | FFAR1 (0.40) | ALOX5EPHX2SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL4441407 | 0.83 | FFAR1 (0.40) | ALOX5EPHX2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |