Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 4/20 | 0.41 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440389 | 1.00 | USP2 (0.58) | USP2KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL1482480 | 0.86 | NPC1 (0.51) | USP2ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL1921934 | 0.82 | USP2 (0.58) | USP2KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL17869804 | 0.81 | USP2 (0.57) | USP2KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL15546888 | 0.80 | MYC (0.41) | USP2KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL24691035 | 0.79 | USP2 (0.54) | USP2KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL4435359 | 0.79 | USP2 (0.58) | USP2KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL607498 | 0.79 | USP2 (0.58) | USP2KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL1665710 | 0.79 | USP2 (0.58) | USP2KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL26648425 | 0.79 | USP2 (0.54) | USP2KDM4EALDH1A1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |