Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 8/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14598813 | 0.88 | MAPT (0.50) | USP2KDM4EHRH3ALDH1A1MEN1 | |
| SCHEMBL4410499 | 0.84 | ALDH1A1 (0.54) | ADRA2AADRA2CADRA2BALDH1A1POLB | |
| SCHEMBL65016 | 0.84 | ALDH1A1 (0.54) | ADRA2AADRA2CADRA2BALDH1A1POLB | |
| SCHEMBL4409961 | 0.84 | ALDH1A1 (0.54) | ADRA2AADRA2CADRA2BALDH1A1POLB | |
| SCHEMBL4432207 | 0.82 | USP2 (0.58) | USP2KDM4ECHEK1HRH3CASR | |
| SCHEMBL4440389 | 0.82 | USP2 (0.58) | USP2KDM4ECHEK1HRH3CASR | |
| SCHEMBL64983 | 0.80 | HTT (0.50) | ESR1ESR2ALDH1A1MEN1POLB | |
| SCHEMBL17289850 | 0.80 | USP2 (0.50) | USP2KDM4ECHEK1HRH3HSD11B1 | |
| SCHEMBL12662987 | 0.80 | ESR1 (0.52) | ESR1ESR2ADRA2AADRA2CADRA2B | |
| SCHEMBL3567530 | 0.80 | ESR1 (0.52) | ESR1ESR2ADRA2AADRA2CADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328872-A1 | PYRAZOLE COMPOUNDS 436 | AstraZeneca AB (SE) | 2011-06-08 | — | — | EP | disclosed |
| US-20090318468-A1 | PYRAZOLE COMPOUNDS 436 | ASTRAZENECA AB (SE) | 2009-12-24 | — | — | US | disclosed |
| WO-2009153592-A1 | PYRAZOLE COMPOUNDS 436 | ASTRAZENECA AB (SE) | 2009-12-23 | — | — | WO | disclosed |
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2007099166-A1 | PYRAZOLO-PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318468-A1 | PYRAZOLE COMPOUNDS 436 | CYP3A43, CYP3A7, CYP3A4 | USP2 4389/4885KDM4E 4254/4885CHEK1 1782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.