Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665710 | 1.00 | USP2 (0.58) | USP2KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL24115187 | 0.86 | NPC1 (0.51) | USP2KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL7400655 | 0.85 | CHRNA7 (0.47) | USP2MAPTCA1FGFR1NTRK1 | |
| SCHEMBL17530499 | 0.85 | CHRNA7 (0.47) | USP2MAPTCA1FGFR1NTRK1 | |
| SCHEMBL1922775 | 0.82 | USP2 (0.58) | USP2KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL64018 | 0.82 | ALDH1A1 (0.57) | KDM4EALDH1A1KMT2ATDP1MEN1 | |
| SCHEMBL607498 | 0.79 | USP2 (0.58) | USP2KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL4440389 | 0.79 | USP2 (0.58) | USP2KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL4432207 | 0.79 | USP2 (0.58) | USP2KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL20046603 | 0.79 | GPR119 (0.42) | USP2ALDH1A1CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |