Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65150 | 0.87 | ABCB1 (0.49) | ABCB1ROCK2ROCK1NR3C2PRKAB2 | |
| SCHEMBL4554792 | 0.86 | SIRT2 (0.40) | ABCB1ROCK2ROCK1NR3C2KDM4E | |
| SCHEMBL4562857 | 0.80 | HPGD (0.46) | ABCB1ROCK2ROCK1NR3C2PRKAB2 | |
| SCHEMBL64118 | 0.79 | KCNQ3 (0.52) | ABCB1ROCK2ROCK1NR3C2SMN1; SMN2 | |
| SCHEMBL62554 | 0.79 | ABCB1 (0.47) | ABCB1ROCK2ROCK1NR3C2SMN1; SMN2 | |
| SCHEMBL62361 | 0.79 | ABCB1 (0.47) | ABCB1ROCK2ROCK1NR3C2SMN1; SMN2 | |
| SCHEMBL1853874 | 0.78 | ABCB1 (0.45) | ABCB1ROCK2ROCK1NR3C2SMN1; SMN2 | |
| SCHEMBL63192 | 0.78 | ABCB1 (0.43) | ABCB1ROCK2ROCK1NR3C2SMN1; SMN2 | |
| SCHEMBL64528 | 0.77 | P4HTM (0.53) | ABCB1ROCK2ROCK1NR3C2P2RY14 | |
| SCHEMBL64697 | 0.77 | ABCB1 (0.46) | ABCB1ROCK2ROCK1NR3C2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |