Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL62371 | 0.88 | KDM4E (0.47) | SIRT2SIRT1SIRT3KDM4EHPGD | |
| SCHEMBL4432284 | 0.86 | ABCB1 (0.43) | KDM4EHPGDABCB1NR3C2NTRK1 | |
| SCHEMBL63821 | 0.79 | KDM4E (0.64) | SIRT2SIRT1SIRT3KDM4EHPGD | |
| SCHEMBL63343 | 0.78 | RAB9A (0.43) | KDM4EABCB1NTRK1RXFP1ROCK2 | |
| SCHEMBL63704 | 0.76 | RAB9A (0.51) | MEN1KMT2ARXFP1 | |
| SCHEMBL62401 | 0.75 | NR3C2 (0.48) | ABCB1NR3C2KMT2ANTRK1ROCK2 | |
| SCHEMBL63678 | 0.74 | HDAC1 (0.48) | KDM4EABCB1NR3C2KMT2ANTRK1 | |
| SCHEMBL62764 | 0.73 | MAPT (0.51) | KDM4EFGFR1LMNA | |
| SCHEMBL64148 | 0.72 | KMT2A (0.54) | KDM4EHPGDABCB1MEN1KMT2A | |
| SCHEMBL63175 | 0.72 | KDM4E (0.47) | KDM4EHPGDABCB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |