Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ACP1 | P24666 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 2/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1581197 | 0.93 | TDP1 (0.51) | MTNR1AMTNR1BHDAC1HDAC8HDAC6 | |
| SCHEMBL4433139 | 0.85 | MAPT (0.57) | KMT2AMCHR1MEN1ACP1GAA | |
| Hydrochloric Acid SCHEMBL4441377 | 0.83 | MAPT (0.56) | KMT2AMCHR1MEN1ACP1GAA | |
| SCHEMBL1582274 | 0.83 | ACP1 (0.51) | MTNR1AMTNR1BHDAC1HDAC8HDAC6 | |
| SCHEMBL11117603 | 0.83 | MAPT (0.56) | MTNR1AMTNR1BKMT2ATDP1GAK | |
| SCHEMBL4434676 | 0.81 | MCHR1 (0.49) | KMT2ATDP1MCHR1MEN1KDM4E | |
| SCHEMBL15130900 | 0.80 | CASR (0.63) | KMT2AMEN1HTTCASR | |
| SCHEMBL3648940 | 0.80 | ALDH1A1 (0.44) | ACP1HTTGAAMAPTSIRT2 | |
| SCHEMBL27610543 | 0.79 | ALDH1A1 (0.53) | HDAC1HDAC8MCHR1MAPT | |
| SCHEMBL11114174 | 0.79 | MTNR1A (0.66) | MTNR1AMTNR1BKMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |