Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTBP2 | P56545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171877 | 0.83 | CTBP2 (0.48) | CTBP2L3MBTL1RAB9ANPC1LTB4R | |
| SCHEMBL6625005 | 0.82 | TDP1 (0.59) | CTBP2TDP1KMT2APOLBAPEX1 | |
| SCHEMBL27614321 | 0.82 | KMT2A (0.49) | L3MBTL1NPC1LTB4RLTB4R2HPGD | |
| SCHEMBL4430452 | 0.82 | CES2 (0.52) | RAB9ANPC1LTB4RLTB4R2MEN1 | |
| SCHEMBL24835513 | 0.78 | LTB4R (0.49) | CTBP2L3MBTL1RAB9ANPC1LTB4R | |
| SCHEMBL27807648 | 0.78 | TDP1 (0.54) | CTBP2L3MBTL1RAB9ANPC1LTB4R | |
| Toluene SCHEMBL5404912 | 0.77 | TDP1 (0.53) | CTBP2L3MBTL1LTB4RLTB4R2TDP1 | |
| SCHEMBL20812008 | 0.77 | HPGD (0.49) | CTBP2L3MBTL1RAB9ANPC1LTB4R | |
| SCHEMBL8064820 | 0.77 | HDAC4 (0.49) | CTBP2L3MBTL1RAB9ANPC1LTB4R | |
| SCHEMBL2384372 | 0.77 | HPGD (0.45) | CTBP2L3MBTL1RAB9ANPC1LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |