Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CCR2 | P41597 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 5/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4435541 | 1.00 | EPHX2 (0.44) | EPHX2ALOX5KMT2AMAPTCCR2 | |
| SCHEMBL4430301 | 1.00 | EPHX2 (0.44) | EPHX2ALOX5KMT2AMAPTCCR2 | |
| SCHEMBL4432373 | 0.94 | KDM4E (0.43) | EPHX2ALOX5KMT2ACCR2MEN1 | |
| SCHEMBL4429519 | 0.94 | KDM4E (0.43) | EPHX2ALOX5KMT2ACCR2MEN1 | |
| SCHEMBL4432984 | 0.92 | LMNA (0.41) | EPHX2ALOX5MAPTAKR1C3AKR1C2 | |
| SCHEMBL4433176 | 0.92 | LMNA (0.41) | EPHX2ALOX5MAPTAKR1C3AKR1C2 | |
| SCHEMBL4433698 | 0.92 | LMNA (0.41) | EPHX2ALOX5MAPTAKR1C3AKR1C2 | |
| SCHEMBL4431215 | 0.90 | KMT2A (0.50) | EPHX2ALOX5KMT2AMAPTMEN1 | |
| SCHEMBL4441614 | 0.90 | KMT2A (0.50) | EPHX2ALOX5KMT2AMAPTMEN1 | |
| SCHEMBL4434528 | 0.88 | KMT2A (0.43) | EPHX2ALOX5KMT2AMAPTCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | claimed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | claimed |