Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433176 | 1.00 | LMNA (0.41) | LMNAUTS2RAKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL4433698 | 1.00 | LMNA (0.41) | LMNAUTS2RAKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL4429519 | 0.92 | KDM4E (0.43) | AKR1C3AKR1C2ALDH1A1CTDSP1KDM4E | |
| SCHEMBL4433016 | 0.92 | EPHX2 (0.44) | LMNAAKR1C3AKR1C2ALDH1A1MAPT | |
| SCHEMBL4432373 | 0.92 | KDM4E (0.43) | AKR1C3AKR1C2ALDH1A1CTDSP1KDM4E | |
| SCHEMBL4435541 | 0.92 | EPHX2 (0.44) | LMNAAKR1C3AKR1C2ALDH1A1MAPT | |
| SCHEMBL4430301 | 0.92 | EPHX2 (0.44) | LMNAAKR1C3AKR1C2ALDH1A1MAPT | |
| SCHEMBL4440206 | 0.88 | ALDH1A1 (0.48) | LMNAALDH1A1CTDSP1KDM4ETDP1 | |
| SCHEMBL4434033 | 0.88 | ALDH1A1 (0.48) | LMNAALDH1A1CTDSP1KDM4ETDP1 | |
| SCHEMBL4434528 | 0.86 | KMT2A (0.43) | LMNAAKR1C3AKR1C2ALDH1A1CTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |