Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4435099 | 0.89 | BRD4 (0.50) | SPHK1BRD4GPR119HSD11B2MEN1 | |
| SCHEMBL1833859 | 0.83 | KDM4E (0.40) | KDM4EPKMSPHK1BRD4GPR119 | |
| SCHEMBL1833860 | 0.83 | KDM4E (0.40) | KDM4EPKMSPHK1BRD4GPR119 | |
| SCHEMBL1833862 | 0.83 | KDM4E (0.40) | KDM4EPKMSPHK1BRD4GPR119 | |
| SCHEMBL4594516 | 0.80 | SPHK1 (0.48) | KDM4EPKMSPHK1BRD4HSD11B2 | |
| SCHEMBL3607483 | 0.80 | SPHK1 (0.41) | KDM4EPKMSPHK1BRD4GPR119 | |
| SCHEMBL3607479 | 0.80 | SPHK1 (0.41) | KDM4EPKMSPHK1BRD4GPR119 | |
| SCHEMBL3607486 | 0.80 | SPHK1 (0.41) | KDM4EPKMSPHK1BRD4GPR119 | |
| SCHEMBL14350826 | 0.79 | SPHK1 (0.42) | KDM4EPKMSPHK1BRD4GPR119 | |
| SCHEMBL3612721 | 0.79 | SPHK1 (0.44) | KDM4EPKMSPHK1BRD4GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114906-A1 | NOVEL 2-AMINOOXAZOLINES AS TAAR1 LIGANDS FOR CNS DISORDERS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008092785-A1 | NOVEL 2-AMINOOXAZOLINES AS TAAR1 LIGANDS FOR CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-07 | — | — | WO | disclosed |