Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 2/20 | 0.36 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | VEGFA | P15692 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433026 | 0.89 | KDM4E (0.43) | BRD4MEN1KMT2ASPHK1STS | |
| SCHEMBL3616035 | 0.80 | BRD4 (0.49) | BRD4MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL3616039 | 0.80 | BRD4 (0.49) | BRD4MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL3616041 | 0.80 | BRD4 (0.49) | BRD4MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL18959547 | 0.79 | BRD4 (0.47) | BRD4MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL1833586 | 0.78 | BRD4 (0.47) | BRD4MEN1KMT2ASPHK1GPR119 | |
| SCHEMBL1833587 | 0.78 | BRD4 (0.47) | BRD4MEN1KMT2ASPHK1GPR119 | |
| SCHEMBL3838091 | 0.77 | BRD4 (0.47) | BRD4MEN1KMT2ASTS | |
| SCHEMBL3838083 | 0.77 | BRD4 (0.47) | BRD4MEN1KMT2ASTS | |
| SCHEMBL6486940 | 0.77 | BRD4 (0.46) | BRD4MEN1KMT2AHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114906-A1 | NOVEL 2-AMINOOXAZOLINES AS TAAR1 LIGANDS FOR CNS DISORDERS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008092785-A1 | NOVEL 2-AMINOOXAZOLINES AS TAAR1 LIGANDS FOR CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-07 | — | — | WO | disclosed |