Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.48 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16325799 | 0.90 | SPHK1 (0.49) | SPHK1HSD11B2BRD4CHRM2CHRM1 | |
| SCHEMBL13613722 | 0.90 | SPHK1 (0.49) | SPHK1HSD11B2BRD4CHRM2CHRM1 | |
| SCHEMBL28067987 | 0.90 | SPHK1 (0.49) | SPHK1HSD11B2BRD4CHRM2CHRM1 | |
| SCHEMBL2328927 | 0.86 | SPHK1 (0.46) | SPHK1HSD11B2BRD4CHRM2CHRM1 | |
| SCHEMBL1863728 | 0.86 | SPHK1 (0.46) | SPHK1HSD11B2BRD4CHRM2CHRM1 | |
| SCHEMBL1863729 | 0.86 | SPHK1 (0.46) | SPHK1HSD11B2BRD4CHRM2CHRM1 | |
| SCHEMBL14489664 | 0.86 | SPHK1 (0.46) | SPHK1HSD11B2BRD4CHRM2CHRM1 | |
| SCHEMBL2328925 | 0.86 | SPHK1 (0.46) | SPHK1HSD11B2BRD4CHRM2CHRM1 | |
| SCHEMBL1526136 | 0.85 | SPHK1 (0.50) | SPHK1HSD11B2BRD4CHRM2CHRM1 | |
| SCHEMBL20621505 | 0.85 | SPHK1 (0.53) | SPHK1HSD11B2BRD4CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539731-B9 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| EP-1539731-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-02 | — | — | EP | disclosed |
| US-20050203172-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2005-09-15 | — | — | US | disclosed |
| US-20040242871-A1 | Novel arylheteroalkylamine derivatives | ASTRAZENECA AB (SE) | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242871-A1 | Novel arylheteroalkylamine derivatives | CYP1A1, NOS3, NOS1 | SPHK1 1994/4885HSD11B2 894/4885BRD4 3935/4885 |
| US-20050203172-A1 | Novel compounds | NOS3, NOS1, NOS2 | SPHK1 2232/4885HSD11B2 1665/4885BRD4 3901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.