Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4446049 | 1.00 | VCAM1 (0.53) | VCAM1ALDH1A1ARPELP1KMT2A | |
| SCHEMBL8768519 | 0.84 | VCAM1 (0.46) | VCAM1ALDH1A1ARPELP1KMT2A | |
| SCHEMBL4125942 | 0.84 | VCAM1 (0.55) | VCAM1ALDH1A1ARPELP1KMT2A | |
| SCHEMBL29625012 | 0.84 | VCAM1 (0.55) | VCAM1ALDH1A1ARPELP1KMT2A | |
| SCHEMBL7087722 | 0.84 | VCAM1 (0.55) | VCAM1ALDH1A1ARPELP1KMT2A | |
| SCHEMBL5004220 | 0.83 | VCAM1 (0.51) | VCAM1ALDH1A1ARPELP1KMT2A | |
| SCHEMBL5734347 | 0.80 | VCAM1 (0.68) | VCAM1ALDH1A1KMT2AHPGDNPSR1 | |
| SCHEMBL9652429 | 0.79 | AKR1C3 (0.49) | ALDH1A1KMT2AHPGDAKR1C4AKR1C3 | |
| SCHEMBL1291038 | 0.79 | MAPK1 (0.59) | VCAM1ALDH1A1KMT2AHPGDNPSR1 | |
| SCHEMBL29946151 | 0.79 | MAPK1 (0.59) | VCAM1ALDH1A1KMT2AHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | disclosed |
| US-5872280-A | RESPIRATORY SYSTEM DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-02-16 | — | — | US | disclosed |