SCHEMBL443318

SCHEMBL443318

Fc1c[c]cc(Cl)c1Cl

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL96258 0.78
SCHEMBL148680 0.78
SCHEMBL444678 0.76
SCHEMBL443970 0.74
SCHEMBL2282068 0.74
SCHEMBL2288283 0.74
SCHEMBL2286037 0.74
SCHEMBL144002 0.73
SCHEMBL2288510 0.70 CTRC (0.33)
SCHEMBL2285200 0.70 HTR2A (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2684871-B1 Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives HOFFMANN LA ROCHE (CH) 2016-05-04 EP claimed
US-20240043446-A1 ANTHELMINTIC COMPOUNDS COMPRISING A THIENOPYRIDINE STRUCTURE INTERVET INC. (US) 2024-02-08 US disclosed
US-20240043385-A1 ANTHELMINTIC COMPOUNDS COMPRISING A PYRIDINE STRUCTURE INTERVET INC. (US) 2024-02-08 US disclosed
EP-4259636-A1 ANTHELMINTIC COMPOUNDS COMPRISING A THIENOPYRIDINE STRUCTURE Intervet International B.V. (NL) 2023-10-18 EP disclosed
EP-4259606-A1 ANTHELMINTIC COMPOUNDS COMPRISING A PYRIDINE STRUCTURE Intervet International B.V. (NL) 2023-10-18 EP disclosed
US-20230148316-A1 ANTHELMINTIC COMPOUNDS COMPRISING A QUINOLINE STRUCTURE INTERVET INC. (US) 2023-05-11 US disclosed
EP-4077322-A1 ANTHELMINTIC COMPOUNDS COMPRISING AZAINDOLES STRUCTURE Intervet International B.V. (NL) 2022-10-26 EP disclosed
CN-114727991-A Arylmethylene heterocyclic compounds as Kv1.3 potassium SHAKER channel blockers D·E·萧尔研究有限责任公司 2022-07-08 CN disclosed
WO-2022122988-A1 ANTHELMINTIC COMPOUNDS COMPRISING A THIENOPYRIDINE STRUCTURE INTERVET INTERNATIONAL B.V. (NL) 2022-06-16 WO disclosed
WO-2022122987-A1 ANTHELMINTIC COMPOUNDS COMPRISING A PYRIDINE STRUCTURE INTERVET INTERNATIONAL B.V. (NL) 2022-06-16 WO disclosed
US-6903125-B2 Tetrahydro-2H-thiopyran-4-carboxamide derivative YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 2005-06-07 US disclosed
US-20050032855-A1 Tetrahydro-2H-thiopyran-4-carboxamide derivative YAMANOUCHI PHARMACEUTICAL CO., LTD. 2005-02-10 US disclosed
US-20040034232-A1 Amide derivative ASTELLAS PHARMA INC. (JP) 2004-02-19 US disclosed
EP-1340750-A1 AMIDE DERIVATIVES YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 2003-09-03 EP disclosed
EP-0812834-B1 PROCESS FOR THE PREPARATION OF 3-(SUBSTITUTED PHENYL)-5-ALKYLIDENE-1,3-OXAZOLIDINE-2,4-DIONE DERIVATIVES SAGAMI CHEM RES (JP) 2001-06-20 EP disclosed
US-6090946-A Process for the preparation of 3-(substituted phenyl)-5-alkylidene-1,3-oxazolidine-2,4-dione derivatives SAGAMI CHEMICAL RESEARCH CENTER (JP) 2000-07-18 US disclosed
EP-0812834-A1 PROCESS FOR THE PREPARATION OF 3-(SUBSTITUTED PHENYL)-5-ALKYLIDENE-1,3-OXAZOLIDINE-2,4-DIONE DERIVATIVES SAGAMI CHEMICAL RESEARCH CENTER (JP) 1997-12-17 EP disclosed
US-4175125-A USING HALOGENATED PHENYLTHIOACETAMIDO CEPHALOSPORANIC ACID DERIVAT ELI LILLY AND COMPANY (US) 1979-11-20 US disclosed
US-4131672-A HALOGENATED PHENYLTHIOACETAMIDO CEPHALOSPORANIC ACIDS ELI LILLY AND COMPANY (US) 1978-12-26 US disclosed
US-4056676-A ANTIBIOTIC ELI LILLY AND COMPANY (US) 1977-11-01 US disclosed