Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433283 | 0.88 | KDM4E (0.43) | KDM4EALDH1A1GLAHSD11B1ACHE | |
| SCHEMBL4184832 | 0.84 | DPP4 (0.47) | KDM4EALDH1A1GLAHSD11B1ACHE | |
| SCHEMBL4443375 | 0.81 | SMN1; SMN2 (0.42) | KDM4EALDH1A1ACHEPDE10AMAPT | |
| SCHEMBL4441765 | 0.78 | ALDH1A1 (0.50) | KDM4EALDH1A1KMT2ABACE1MAPT | |
| SCHEMBL16597047 | 0.77 | MBNL1 (0.54) | KDM4EALDH1A1GLAHSD11B1ACHE | |
| SCHEMBL4174565 | 0.75 | ALDH1A1 (0.44) | KDM4EALDH1A1GLAHSD11B1ACHE | |
| SCHEMBL4167541 | 0.74 | KDM4E (0.45) | KDM4EALDH1A1GLAHSD11B1ACHE | |
| SCHEMBL4185729 | 0.74 | CNR1 (0.46) | KDM4EALDH1A1GLAHSD11B1ACHE | |
| SCHEMBL4191733 | 0.74 | DPP4 (0.47) | KDM4EALDH1A1GLAHSD11B1ACHE | |
| SCHEMBL1887296 | 0.74 | DHODH (0.44) | KDM4EALDH1A1PDE2APDE10ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |