Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA7 | P43166 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11508000 | 0.88 | CA12 (0.43) | NPC1RAB9ACA12CA1CA7 | |
| SCHEMBL13952764 | 0.78 | APOBEC3A (0.36) | NPC1RAB9ACA12CA1CA7 | |
| SCHEMBL30150440 | 0.77 | NPC1 (0.51) | NPC1RAB9ACA12CA1CA7 | |
| SCHEMBL1799316 | 0.76 | CA12 (0.56) | CA12CA1CA7CA9CA14 | |
| SCHEMBL31119234 | 0.76 | CA12 (0.56) | CA12CA1CA7CA9CA14 | |
| SCHEMBL987451 | 0.76 | GAA (0.41) | CA12CA1CA7CA9CA14 | |
| SCHEMBL2704176 | 0.76 | ACACB (0.43) | NPC1RAB9ACA12CA1CA7 | |
| SCHEMBL3434561 | 0.76 | CA12 (0.56) | CA12CA1CA7CA9CA14 | |
| SCHEMBL6196567 | 0.76 | CA12 (0.56) | CA12CA1CA7CA9CA14 | |
| SCHEMBL96290 | 0.76 | CA12 (0.56) | NPC1CA12CA1CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125859-B1 | ESTRATRIENE DERIVATIVES AND THEIR USES AS 17BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | ABBOTT PRODUCTS GMBH (DE) | 2013-05-15 | — | — | EP | disclosed |
| US-8080540-B2 | Therapeutically active triazoles and their use | ABBOTT PRODUCTS GMBH (DE) | 2011-12-20 | — | — | US | disclosed |
| EP-2125859-A2 | ESTRATRIENE DERIVATIVES AND THEIR USES AS 17BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Solvay Pharmaceuticals GmbH (DE) | 2009-12-02 | — | — | EP | disclosed |
| US-20080146531-A1 | Therapeutically Active Triazoles and Their Use | SOLVAY PHARMACEUTICALS GMBH (DE) | 2008-06-19 | — | — | US | disclosed |
| WO-2008034796-A2 | ESTRATRIENE DERIVATIVES AND THEIR USES AS 17BETA-HYDR0XYSTER0ID DEHYDROGENASE INHIBITORS | SOLVAY PHARMACEUTICALS GMBH (DE) | 2008-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146531-A1 | Therapeutically Active Triazoles and Their Use | HSD17B2, HSD17B3, HSD17B1 | NPC1 1632/4885RAB9A 4154/4885CA12 2806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.