Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.34 |
| ▸ | ERN1 | O75460 | 4/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885299 | 0.86 | PDE4D (0.43) | MAPTTDP1CES2PDE4DERN1 | |
| SCHEMBL4429229 | 0.78 | PDE4D (0.48) | TDP1PDE4DERN1MDM2 | |
| SCHEMBL885394 | 0.77 | PDE4D (0.40) | PDE4DERN1MDM2 | |
| SCHEMBL885267 | 0.77 | PDE4D (0.42) | PDE4D | |
| SCHEMBL4427860 | 0.76 | NPC1 (0.39) | PDE4DERN1 | |
| SCHEMBL4434300 | 0.74 | PDE4D (0.45) | PDE4D | |
| SCHEMBL4438478 | 0.74 | PDE4D (0.39) | MAPTPDE4DERN1 | |
| SCHEMBL885062 | 0.74 | PDE4D (0.50) | PDE4D | |
| SCHEMBL885169 | 0.73 | PDE4D (0.52) | PDE4D | |
| SCHEMBL885389 | 0.71 | PDE4D (0.51) | TDP1PDE4DERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | disclosed |