Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.80 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2218697 | 0.89 | HRH3 (1.00) | HRH3USP2LMNAKMT2AMEN1 | |
| SCHEMBL2218090 | 0.88 | HRH3 (1.00) | HRH3USP2 | |
| SCHEMBL2216419 | 0.86 | HRH3 (1.00) | HRH3USP2 | |
| SCHEMBL2215845 | 0.85 | HRH3 (0.72) | HRH3USP2LMNAKMT2A | |
| SCHEMBL2220961 | 0.77 | HRH3 (1.00) | HRH3 | |
| SCHEMBL2219845 | 0.76 | HRH3 (1.00) | HRH3LMNAKMT2AHTTMEN1 | |
| SCHEMBL29479422 | 0.74 | HRH3 (0.58) | HRH3KMT2AKDM4EMEN1 | |
| SCHEMBL2216786 | 0.74 | HRH3 (1.00) | HRH3LMNAKMT2AHTTMEN1 | |
| SCHEMBL4433079 | 0.73 | HRH3 (0.47) | HRH3USP2HTTMAPK14 | |
| SCHEMBL2218428 | 0.71 | HRH3 (1.00) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125720-A1 | INDOLE AND BENZOTHIOPHENE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008109333-A1 | INDOLE AND BENZOTHIOPHENE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-09-12 | — | — | WO | disclosed |