Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.72 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433508 | 0.85 | HRH3 (0.80) | HRH3USP2KMT2ALMNA | |
| SCHEMBL2218090 | 0.83 | HRH3 (1.00) | HRH3USP2 | |
| SCHEMBL2218697 | 0.83 | HRH3 (1.00) | HRH3USP2KMT2ALMNA | |
| SCHEMBL2216419 | 0.80 | HRH3 (1.00) | HRH3USP2 | |
| SCHEMBL2215173 | 0.77 | POLB (0.52) | HRH3KMT2APOLB | |
| SCHEMBL15265165 | 0.73 | USP2 (0.49) | USP2POLBSMN1; SMN2LMNA | |
| SCHEMBL2220961 | 0.73 | HRH3 (1.00) | HRH3 | |
| SCHEMBL5336442 | 0.73 | MGLL (0.53) | USP2SMN1; SMN2LMNA | |
| SCHEMBL15264811 | 0.73 | MGLL (0.54) | USP2KMT2APOLBSMN1; SMN2 | |
| SCHEMBL522487 | 0.72 | HRH3 (0.70) | HRH3USP2KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178062-A1 | INDOLE AND BENZOTHIOPHENE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-07-21 | — | — | US | disclosed |
| CN-101679249-A | As histamine H 3The indoles of receptor modulators and benzothienyl compounds | JANSSEN PHARMACEUTICA NV | 2010-03-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178062-A1 | INDOLE AND BENZOTHIOPHENE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | HRH3, HRH4, HRH1 | HRH3 1/4885USP2 3136/4885KMT2A 186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.