Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 5/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215173 | 0.83 | POLB (0.52) | HRH3TRIM24TRIM33PIM1PIM3 | |
| SCHEMBL2220800 | 0.79 | TRIM24 (0.58) | TRIM24TRIM33PIM1PIM3HTT | |
| SCHEMBL29950729 | 0.79 | TRIM24 (0.58) | TRIM24TRIM33PIM1PIM3HTT | |
| SCHEMBL5276777 | 0.79 | HTR2A (0.72) | HRH3HTR2AHTR2CDRD4SLC6A2 | |
| Hydrochloric Acid SCHEMBL27498823 | 0.78 | HTR2A (0.70) | HRH3HTR2AHTR2CDRD4SLC6A2 | |
| SCHEMBL4433508 | 0.73 | HRH3 (0.80) | HRH3HTTMAPK14USP2 | |
| SCHEMBL5415543 | 0.71 | PIM1 (0.81) | TRIM24TRIM33PIM1PIM3TSHR | |
| SCHEMBL3582934 | 0.70 | ALDH1A1 (0.68) | TSHRHTTALDH1A1USP2 | |
| SCHEMBL29955386 | 0.69 | TRIM24 (0.66) | TRIM24TRIM33PIM1PIM3PIM2 | |
| SCHEMBL29954763 | 0.69 | TRIM24 (0.70) | TRIM24TRIM33PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125720-A1 | INDOLE AND BENZOTHIOPHENE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008109333-A1 | INDOLE AND BENZOTHIOPHENE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-09-12 | — | — | WO | disclosed |