SCHEMBL443368

SCHEMBL443368

CN(C)Cc1c[nH]c2ccc(Cl)cc12

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 4/20 0.68
GPR84 Q9NQS5 2/20 0.67
HSD17B10 Q99714 2/20 0.60
TSHR P16473 2/20 0.60
KDM4E B2RXH2 1/20 0.60
MEN1 O00255 1/20 0.60
ALDH1A1 P00352 1/20 0.60
CYP3A4 P08684 1/20 0.60
CYP2D6 P10635 1/20 0.60
CYP2C19 P33261 1/20 0.60
KMT2A Q03164 1/20 0.60
HTR2A P28223 4/20 0.59
TRPM8 Q7Z2W7 1/20 0.59
HTR6 P50406 2/20 0.56
IDO1 P14902 1/20 0.52
HTR1A P08908 1/20 0.52
ADRA2A P08913 1/20 0.52
DRD2 P14416 1/20 0.52
ADRA2B P18089 1/20 0.52
ADRA2C P18825 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3018247 0.87 SLC6A4 (0.68) SLC6A4GPR84HSD17B10TSHRKDM4E
SCHEMBL21724167 0.84 MPO (0.68) SLC6A4GPR84HSD17B10TSHRKDM4E
SCHEMBL25380394 0.84 SLC6A4 (0.83) SLC6A4GPR84CYP2D6HTR2ATRPM8
SCHEMBL31415109 0.81 CYP2D6 (0.62) SLC6A4HSD17B10TSHRKDM4EMEN1
SCHEMBL11493839 0.81 CYP2D6 (0.62) SLC6A4HSD17B10TSHRKDM4EMEN1
SCHEMBL27510004 0.81 SLC6A4 (0.51) SLC6A4GPR84HSD17B10TSHRKDM4E
SCHEMBL10119751 0.81 GPR84 (0.73) SLC6A4GPR84HSD17B10TSHRMEN1
SCHEMBL18383117 0.80 GPR84 (1.00) SLC6A4GPR84HTR2ATRPM8HTR6
Bromogramine SCHEMBL1196680 0.80 SLC6A4 (0.68) SLC6A4GPR84HSD17B10TSHRKDM4E
Bromogramine SCHEMBL30279666 0.80 SLC6A4 (0.68) SLC6A4GPR84HSD17B10TSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3862354-A1 INDOLOPYRIDINES AS EG5 KINESIN MODULATORS 4SC AG (DE) 2021-08-11 EP disclosed
EP-2824105-B1 Indolopyridines as Eg5 kinesin modulators 4SC AG (DE) 2021-03-31 EP disclosed
US-8945397-B2 Methods of inhibiting cyanobacteria growth by administering gramine derivatives CYANOTROL, LLC (US) 2015-02-03 US disclosed
US-8945397-B2 Methods of inhibiting cyanobacteria growth by administering gramine derivatives CYANOTROL, LLC (US) 2015-02-03 US disclosed
US-8945397-B2 Methods of inhibiting cyanobacteria growth by administering gramine derivatives CYANOTROL, LLC (US) 2015-02-03 US disclosed
EP-2824105-A1 Indolopyridines as Eg5 kinesin modulators 4SC AG (DE) 2015-01-14 EP disclosed
US-20140110350-A1 METHODS OF INHIBITING CYANOBACTERIA GROWTH BY ADMINISTERING GRAMINE DERIVATIVES SAN FRANCISCO STATE UNIVERSITY (US) 2014-04-24 US disclosed
US-20140110350-A1 METHODS OF INHIBITING CYANOBACTERIA GROWTH BY ADMINISTERING GRAMINE DERIVATIVES SAN FRANCISCO STATE UNIVERSITY (US) 2014-04-24 US disclosed
US-20140110350-A1 METHODS OF INHIBITING CYANOBACTERIA GROWTH BY ADMINISTERING GRAMINE DERIVATIVES SAN FRANCISCO STATE UNIVERSITY (US) 2014-04-24 US disclosed
US-8530493-B2 Indolopyridines as Eg5 kinesin modulators 4SC AG (DE) 2013-09-10 US disclosed
WO-2001051489-A2 METHODS FOR LOWERING URIC ACID LEVELS THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) 2001-07-19 WO disclosed
US-6214991-B1 3-(4,5,7-TRIFLUOROBENZOTHIAZOL-2-YL)METHYL-INDOLE-N-ACETIC ACID, ETHYL ESTER FOR EXAMPLE; TREATING COMPLICATIONS OF DIABETES MELLITUS, SUCH AS CATARACTS, RETINOPATHY, NEPHROPATHY, AND NEUROPATHY THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, INC. 2001-04-10 US disclosed
EP-1066283-A2 SUBSTITUTED INDOLEALKANOIC ACIDS The Institutes for Pharmaceutical Discovery, Inc. (US) 2001-01-10 EP disclosed
WO-2000032180-A2 ANTIHYPERTRIGLYCERIDEMIC, ANTIHYPERGLYCEMIC, ANTI-ANGIOGENIC AND WOUND HEALING SUBSTITUTED INDOLEALKANOIC ACIDS THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, INC. (US) 2000-06-08 WO disclosed
WO-1999050268-A2 SUBSTITUTED INDOLEALKANOIC ACIDS THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, INC. (US) 1999-10-07 WO disclosed
US-5436264-A Adrenergic blocking agents for vasoconstriction and hypotensive agents SYNTEX (U.S.A.) INC. (US) 1995-07-25 US disclosed
EP-0107618-B1 N-SUBSTITUTED-2-(1-IMIDAZOLYL)-INDOLES CIBA-GEIGY AG (CH) 1986-07-16 EP disclosed
US-4539410-A THROMBOXANE SYNEHETASE INHIBITORS CIBA-GEIGY CORPORATION (US) 1985-09-03 US disclosed
EP-0107618-A1 N-substituted-2-(1-imidazolyl)-indoles CIBA-GEIGY AG (CH) 1984-05-02 EP disclosed
US-4273782-A FOR USE IN CARDIOVASCULAR DISORDERS AND COMPLICATIONS OF DIABETES PFIZER INC. (US) 1981-06-16 US disclosed