Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.71 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25845543 | 0.84 | MAPT (0.70) | SIRT6ADRB1MAPTPOLBALDH1A1 | |
| SCHEMBL27292767 | 0.84 | SIRT6 (0.66) | SIRT6ADRB1MAPTPOLBALDH1A1 | |
| SCHEMBL25845752 | 0.84 | SIRT6 (0.66) | SIRT6ADRB1MAPTPOLBALDH1A1 | |
| SCHEMBL7526992 | 0.84 | SIRT6 (1.00) | SIRT6ADRB1MAPTPOLBALDH1A1 | |
| SCHEMBL336262 | 0.84 | SIRT6 (1.00) | SIRT6ADRB1MAPTPOLBALDH1A1 | |
| SCHEMBL16206952 | 0.82 | SIRT6 (0.72) | SIRT6ADRB1MAPTPOLBALDH1A1 | |
| SCHEMBL29986031 | 0.82 | MEN1 (0.71) | SIRT6ADRB1MAPTPOLBALDH1A1 | |
| SCHEMBL6152151 | 0.82 | SIRT6 (0.96) | SIRT6ADRB1MAPTPOLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL1814630 | 0.82 | SIRT6 (0.96) | SIRT6ADRB1MAPTPOLBALDH1A1 | |
| SCHEMBL6151805 | 0.82 | SIRT6 (0.96) | SIRT6ADRB1MAPTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |