Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 4/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 5/20 | 0.37 |
| ▸ | SLC16A1 | P53985 | 5/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13624088 | 0.81 | HTR2A (0.40) | KMOTRPM8CACNA1H | |
| SCHEMBL3438334 | 0.76 | HCAR3 (0.56) | KMOTRPM8PLA2G4AHCAR3 | |
| SCHEMBL17316596 | 0.73 | KDM4E (0.54) | KMOTRPM8CACNA1H | |
| SCHEMBL250286 | 0.71 | HTR2A (0.49) | KMOCACNA1H | |
| SCHEMBL29769123 | 0.70 | KMO (0.45) | KMO | |
| SCHEMBL7071662 | 0.70 | KMO (0.45) | KMO | |
| SCHEMBL30147500 | 0.69 | MAOB (0.48) | CACNA1H | |
| SCHEMBL20594117 | 0.69 | KDM4E (0.54) | CACNA1HPLA2G4A | |
| SCHEMBL904726 | 0.69 | SLC5A2 (0.46) | KMOTRPM8CACNA1HPLA2G4A | |
| SCHEMBL904672 | 0.69 | MAPT (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137178-A2 | NOVEL VANILLOID RECEPTOR LIGANDS AND THE USE THEREOF FOR THE PRODUCTION OF PHARMACEUTICALS | Grünenthal GmbH (DE) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008125342-A2 | NOVEL VANILLOID RECEPTOR LIGANDS AND THE USE THEREOF FOR THE PRODUCTION OF PHARMACEUTICALS | Grünenthal GmbH (DE) | 2008-10-23 | — | — | WO | disclosed |