Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438606 | 0.90 | PDE4A (0.42) | PDE4AFFAR1KCNH2 | |
| SCHEMBL4432136 | 0.88 | FFAR1 (0.40) | PDE4AFFAR1KCNH2 | |
| SCHEMBL4432348 | 0.88 | FFAR1 (0.40) | PDE4AFFAR1KCNH2 | |
| SCHEMBL4432376 | 0.88 | PDE4A (0.42) | PDE4A | |
| Hydrochloric Acid SCHEMBL4434483 | 0.87 | FFAR1 (0.40) | PDE4AFFAR1KCNH2 | |
| Hydrochloric Acid SCHEMBL4441407 | 0.87 | FFAR1 (0.40) | PDE4AFFAR1KCNH2 | |
| SCHEMBL3738382 | 0.79 | FFAR1 (0.39) | PDE4AFFAR1KCNH2SYK | |
| SCHEMBL4429160 | 0.78 | PDE4A (0.43) | PDE4A | |
| SCHEMBL4429325 | 0.78 | PDE4A (0.43) | PDE4A | |
| SCHEMBL4434762 | 0.78 | PDE4A (0.42) | PDE4AFFAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |