Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 9/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432348 | 1.00 | FFAR1 (0.40) | FFAR1PDE4AALOX5EPHX2SLC6A2 | |
| Hydrochloric Acid SCHEMBL4441407 | 0.99 | FFAR1 (0.40) | FFAR1PDE4AALOX5EPHX2SLC6A2 | |
| Hydrochloric Acid SCHEMBL4434483 | 0.99 | FFAR1 (0.40) | FFAR1PDE4AALOX5EPHX2SLC6A2 | |
| SCHEMBL4429756 | 0.89 | PDE4A (0.42) | FFAR1PDE4ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4434762 | 0.89 | PDE4A (0.42) | FFAR1PDE4ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4434475 | 0.88 | PDE4A (0.41) | FFAR1PDE4AKCNH2 | |
| SCHEMBL4436355 | 0.85 | MTNR1A (0.41) | ALOX5EPHX2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4433172 | 0.85 | MTNR1A (0.41) | ALOX5EPHX2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4431479 | 0.84 | ALOX5 (0.39) | ALOX5EPHX2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4432382 | 0.84 | ALOX5 (0.39) | ALOX5EPHX2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |