SCHEMBL4434527

SCHEMBL4434527

COc1ccccc1C(S)C(C)CO

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.45
HTT P42858 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
AGTR1 P30556 1/20 0.45
LMNA P02545 1/20 0.45
CYP1A2 P05177 1/20 0.45
CA1 P00915 3/20 0.41
CA2 P00918 3/20 0.41
CA12 O43570 1/20 0.41
CA4 P22748 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41
TP53 P04637 1/20 0.39
TSHR P16473 1/20 0.39
KCNK3 O14649 1/20 0.39
KCNK9 Q9NPC2 1/20 0.39
ACHE P22303 1/20 0.39
TRPA1 O75762 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22838526 0.81 AGTR1 (0.47) POLBHTTNPSR1L3MBTL1AGTR1
SCHEMBL8623909 0.78 CA1 (0.55) POLBHTTNPSR1L3MBTL1LMNA
SCHEMBL15328802 0.77 AGTR1 (0.50) POLBHTTNPSR1L3MBTL1AGTR1
SCHEMBL15328772 0.77 AGTR1 (0.50) POLBHTTNPSR1L3MBTL1AGTR1
SCHEMBL21323401 0.74 CA1 (0.55) POLBHTTNPSR1L3MBTL1CA1
SCHEMBL21816513 0.73 CYP1A2 (0.55) POLBHTTNPSR1L3MBTL1AGTR1
SCHEMBL6481118 0.73 CYP1A2 (0.55) POLBHTTNPSR1L3MBTL1AGTR1
SCHEMBL30988788 0.73 CYP1A2 (0.55) POLBHTTNPSR1L3MBTL1AGTR1
SCHEMBL4564350 0.73 ABCB11 (0.49) L3MBTL1CYP1A2CA1CA2CA12
SCHEMBL22738008 0.72 CA1 (0.46) POLBHTTNPSR1L3MBTL1AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2089374-A2 METHOD FOR THE SYNTHESIS OF N- [3- [ (2-METHOXYPHÉNYL) SULFANY] -2- METHYLPROPY]-3,4-DIHYDRO-2H-1,5-BENZOXATHIEPIN-3-AMINE.<0} Pierre Fabre Medicament (FR) 2009-08-19 EP disclosed
WO-2008068403-A2 METHOD FOR THE SYNTHESIS OF N- [3- [ (2-METHOXYPHÉNYL) SULFANYL] -2- METHYLPROPYL] -3,4-DIHYDRO-2H-1,5-BENZOXATHIEPIN-3-AMINE<0} PIERRE FABRE MEDICAMENT (FR) 2008-06-12 WO disclosed