Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018619 | 0.78 | POLB (0.55) | POLBMAPTMAPK1SIRT6KMT2A | |
| SCHEMBL18040090 | 0.67 | SIRT6 (0.54) | POLBMAPTMAPK1SIRT6KMT2A | |
| SCHEMBL10680801 | 0.66 | SIRT6 (0.59) | POLBMAPTSIRT6KMT2AMEN1 | |
| SCHEMBL16206949 | 0.65 | SIRT6 (0.57) | POLBMAPTMAPK1SIRT6KMT2A | |
| SCHEMBL11556051 | 0.65 | POLB (0.71) | POLBMAPTMAPK1SIRT6ALDH1A1 | |
| SCHEMBL15271381 | 0.65 | SIRT6 (0.81) | POLBMAPTSIRT6KMT2AMEN1 | |
| SCHEMBL6151230 | 0.65 | SIRT6 (0.81) | POLBMAPTSIRT6KMT2AMEN1 | |
| SCHEMBL1126486 | 0.64 | SIRT6 (0.56) | POLBMAPTSIRT6KMT2AMEN1 | |
| SCHEMBL374222 | 0.63 | SIRT6 (0.68) | POLBMAPTSIRT6KMT2AMEN1 | |
| SCHEMBL10760949 | 0.63 | MAPT (0.51) | POLBMAPTSIRT6KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097413-A1 | 2-[(2-SUBSTITUTED)-IND0LIZIN-3-YL]-2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G Limited (GB) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008062182-A1 | 2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G LTD (GB) | 2008-05-29 | — | — | WO | disclosed |