Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1126486 | 0.83 | SIRT6 (0.56) | POLBSIRT6MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL942122 | 0.80 | MAPT (0.50) | POLBMAPTMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4434686 | 0.78 | POLB (0.45) | POLBSIRT6MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL22495304 | 0.78 | SIRT6 (0.49) | POLBSIRT6MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL1646405 | 0.76 | ENPP2 (0.49) | POLBSIRT6MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1127229 | 0.76 | KMT2A (0.66) | POLBSIRT6MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12503866 | 0.75 | HRH4 (0.56) | ALDH1A1 | |
| SCHEMBL10680801 | 0.75 | SIRT6 (0.59) | POLBSIRT6MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10274925 | 0.75 | HRH4 (0.51) | MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL15271381 | 0.74 | SIRT6 (0.81) | POLBSIRT6MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097413-B1 | 2-[(2-SUBSTITUTED)-IND0LIZIN-3-YL]-2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G LTD (GB) | 2013-12-25 | — | — | EP | disclosed |
| EP-2173749-B1 | 2-OXO-2- (2-PHENYL-5,6,7,8-TETRAHYDRO-INDOLIZIN-3-YL) -ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ANTIFUNGAL AGENTS | F2G LTD (GB) | 2011-01-12 | — | — | EP | disclosed |