Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 14/20 | 0.57 |
| ▸ | NPC1 | O15118 | 13/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.57 |
| ▸ | PKM | P14618 | 10/20 | 0.53 |
| ▸ | TP53 | P04637 | 8/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12410853 | 0.84 | HTT (1.00) | HTTTSHRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13819896 | 0.82 | HTT (0.46) | HTTTSHRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL21900753 | 0.80 | SMN1; SMN2 (0.54) | TSHRRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL10237028 | 0.79 | HTT (0.72) | HTTTSHRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16543467 | 0.76 | RAB9A (0.61) | HTTTSHRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13820045 | 0.75 | HTT (0.47) | HTTTSHRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL17225312 | 0.74 | HTT (0.45) | HTTTSHRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL17225287 | 0.74 | HTT (0.45) | HTTTSHRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL17225292 | 0.74 | HTT (0.45) | HTTTSHRRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL31478766 | 0.74 | HTT (0.65) | HTTTSHRRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9238647-B2 | P2X3 receptor antagonists for treatment of pain | MERCK SHARP & DOHME CORP. (US) | 2016-01-19 | — | — | US | disclosed |
| US-20120064181-A1 | P2X3 Receptor Antagonists for Treatment of Pain | MERCK SHARP & DOHME LLC | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120064181-A1 | P2X3 Receptor Antagonists for Treatment of Pain | P2RX3, P2RX1, P2RX2 | HTT 3196/4885TSHR 1614/4885RAB9A 3699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.