Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 2/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP7 | Q93009 | 3/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 5/20 | 0.39 |
| ▸ | PLA2G2E | Q9NZK7 | 2/20 | 0.39 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7133144 | 0.81 | BCAT2 (0.43) | BCAT2KMT2AUSP7FOLH1MEN1 | |
| SCHEMBL4789155 | 0.79 | BCAT2 (0.50) | BCAT2PLA2G2AKMT2AMEN1GAA | |
| SCHEMBL31255442 | 0.79 | BCAT2 (0.42) | BCAT2PLA2G2AKMT2AUSP7PLA2G1B | |
| SCHEMBL4444936 | 0.79 | BCAT2 (0.53) | BCAT2PLA2G2AKMT2AMEN1CCNC | |
| SCHEMBL14863333 | 0.78 | PTGDR2 (0.39) | BCAT2PLA2G2APLA2G1BPLA2G2EPLA2G5 | |
| SCHEMBL473259 | 0.77 | DPP4 (0.38) | KMT2AUSP7FOLH1DPP4 | |
| SCHEMBL22371311 | 0.76 | USP7 (0.48) | BCAT2KMT2AUSP7MEN1GAA | |
| Water SCHEMBL474768 | 0.75 | DPP4 (0.37) | KMT2AUSP7FOLH1DPP4 | |
| SCHEMBL4439618 | 0.75 | BCAT2 (0.62) | BCAT2KMT2AMEN1FGFR1FGFR2 | |
| SCHEMBL4530801 | 0.75 | MKNK1 (0.46) | BCAT2PLA2G2AKMT2AMEN1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121621-A1 | LXR AND FXR MODULATORS | Exelixis, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008073825-A1 | LXR AND FXR MODULATORS | EXELIXIS, INC. (US) | 2008-06-19 | — | — | WO | disclosed |