Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | CCR5 | P51681 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.51 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13321698 | 0.89 | MAOB (0.55) | SLC6A4MAOBCCR5ALDH1A1RAB9A | |
| SCHEMBL368071 | 0.87 | SLC6A4 (0.66) | SLC6A4MAOBCCR5ALDH1A1RAB9A | |
| SCHEMBL31644088 | 0.87 | SLC6A4 (0.66) | SLC6A4MAOBCCR5ALDH1A1RAB9A | |
| SCHEMBL18124297 | 0.87 | F2 (0.48) | SLC6A4MAOBCCR5ALDH1A1RAB9A | |
| Bromide SCHEMBL15137373 | 0.85 | F2 (0.47) | SLC6A4MAOBCCR5ALDH1A1RAB9A | |
| SCHEMBL30835101 | 0.85 | RAB9A (0.59) | SLC6A4MAOBCCR5ALDH1A1RAB9A | |
| SCHEMBL7898169 | 0.85 | RAB9A (0.59) | SLC6A4MAOBCCR5ALDH1A1RAB9A | |
| SCHEMBL30628889 | 0.84 | MAOB (0.59) | MAOBRAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL31444115 | 0.84 | LMNA (0.52) | MAOBALDH1A1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL5951406 | 0.84 | LMNA (0.52) | MAOBALDH1A1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186834-A1 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | MICROBIA, INC. (US) | 2009-07-23 | — | — | US | disclosed |
| WO-2008039829-A2 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-04-03 | — | — | WO | disclosed |
| WO-2006102674-A2 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | MICROBIA, INC. (US) | 2006-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186834-A1 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | NPC1L1, CYP46A1, NPC1 | SLC6A4 3627/4885MAOB 1740/4885CCR5 1774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.