Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | DDR2 | Q16832 | 7/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4444272 | 0.81 | GRIK1 (0.54) | DYRK1AABL1GRIK1GRIA1GRIA2 | |
| SCHEMBL4434890 | 0.79 | GRIK1 (0.45) | DYRK1AGRIK1GRIA1GRIA2GRIA3 | |
| SCHEMBL3307100 | 0.76 | ROCK2 (0.56) | DDR2KDR | |
| SCHEMBL3310660 | 0.76 | ROCK2 (0.56) | DDR2KDR | |
| SCHEMBL4442828 | 0.75 | TNKS2 (0.43) | ABL1PARP1MAPK14KIT | |
| SCHEMBL2304728 | 0.75 | DDR2 (0.50) | DDR2MAPK14FGFR1LCKKDR | |
| SCHEMBL2307892 | 0.73 | ABL1 (0.56) | ABL1DDR2MAPK14FGFR1LCK | |
| SCHEMBL2355475 | 0.73 | RAB9A (0.46) | DYRK1AABL1DDR2CSNK2A1MAPK14 | |
| SCHEMBL2304320 | 0.72 | DDR2 (0.53) | ABL1DDR2MAPK14KITFGFR1 | |
| SCHEMBL29815910 | 0.72 | PARP1 (0.62) | DYRK1AKIF11PARP1CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121692-A1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008079965-A1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-07-03 | — | — | WO | disclosed |