Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | ALPL | P05186 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ACR | P10323 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4430204 | 0.88 | MAPT (0.45) | MAPTLMNANPC1RAB9AALPL | |
| Tert-Butyl Formate SCHEMBL27799795 | 0.81 | MAPT (0.40) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL1852946 | 0.81 | HDAC1 (0.53) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL2055693 | 0.81 | CHRNA3 (0.50) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL2055807 | 0.80 | KCNH2 (0.57) | MAPTLMNAALDH1A1 | |
| SCHEMBL7922566 | 0.76 | MAPT (0.59) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL1856463 | 0.73 | HTT (0.38) | MAPTLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL2055712 | 0.71 | KCNH2 (0.51) | MAPTLMNAALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL1857435 | 0.69 | MAPT (0.43) | MAPTALPL | |
| SCHEMBL13322282 | 0.69 | KCNH2 (0.39) | GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118067-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | Siena Biotech S.p.A. (IT) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008087529-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | SIENA BIOTECH S.P.A. (IT) | 2008-07-24 | — | — | WO | disclosed |