Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | ALPL | P05186 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ACR | P10323 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4430204 | 0.90 | MAPT (0.45) | MAPTALPLCA12TP53LTB4R | |
| SCHEMBL4434945 | 0.81 | MAPT (0.49) | MAPTALPLTP53LTB4RALDH1A1 | |
| Tert-Butyl Formate SCHEMBL27799800 | 0.78 | MAPK1 (0.33) | MAPTALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL1856722 | 0.73 | MAPT (0.38) | MAPTLTB4RALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1857435 | 0.73 | MAPT (0.43) | MAPTALPLCA12 | |
| SCHEMBL1855665 | 0.72 | CHRNA7 (0.46) | MAPT | |
| Tert-Butyl Formate SCHEMBL27799796 | 0.69 | MAPT (0.46) | MAPTALPLCA12TP53ALDH1A1 | |
| SCHEMBL29331221 | 0.69 | GPR142 (0.45) | MAPTALPLCA12TP53RAF1 | |
| SCHEMBL4063308 | 0.67 | ALPL (0.41) | MAPTALPLCA12RAF1ALDH1A1 | |
| SCHEMBL1144178 | 0.65 | ALPL (0.54) | MAPTALPLCA12TP53ACR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679287-B | Nicotinic acetylcholine receptor modulators | SIENA BIOTECH SPA | 2013-03-27 | — | — | CN | disclosed |
| CN-101679287-A | nicotinic acetylcholine receptor modulators | SIENA BIOTECH SPA | 2010-03-24 | — | — | CN | disclosed |