Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5058415 | 0.76 | DRD2 (0.59) | DRD2DRD3HTR1A | |
| SCHEMBL2295355 | 0.76 | DRD2 (0.47) | DRD2DRD3 | |
| SCHEMBL5118709 | 0.76 | DRD2 (0.47) | DRD2DRD3 | |
| SCHEMBL2295207 | 0.76 | DRD2 (0.47) | DRD2DRD3 | |
| SCHEMBL8306011 | 0.72 | HTR1A (0.38) | DRD2DRD3HTR1A | |
| Formic Acid SCHEMBL28265868 | 0.70 | DRD2 (0.45) | DRD2DRD3 | |
| SCHEMBL27083132 | 0.69 | PRKACA (0.47) | DRD2DRD3HTR1A | |
| SCHEMBL28810972 | 0.69 | DRD2 (0.41) | DRD2DRD3 | |
| SCHEMBL27949769 | 0.69 | HTT (0.49) | DRD2DRD3 | |
| SCHEMBL629543 | 0.69 | CYP19A1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132184-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | AstraZeneca AB (SE) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008104754-A1 | NOVEL PYRIMIDINE DERIVATIVES 698 | ASTRAZENECA AB (SE) | 2008-09-04 | — | — | WO | disclosed |