Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440233 | 1.00 | PDE4A (0.42) | PDE4AKCNH2P2RX7NTRK1CSF1R | |
| SCHEMBL4441413 | 0.94 | PDE4A (0.41) | PDE4AKCNH2P2RX7 | |
| SCHEMBL4429658 | 0.94 | PDE4A (0.41) | PDE4AKCNH2P2RX7 | |
| SCHEMBL4429537 | 0.91 | PDE4A (0.47) | PDE4AKCNH2 | |
| SCHEMBL4434611 | 0.90 | P2RX7 (0.41) | P2RX7NTRK1CSF1RNTRK2 | |
| SCHEMBL4441632 | 0.90 | P2RX7 (0.41) | P2RX7 | |
| SCHEMBL4441204 | 0.90 | P2RX7 (0.41) | P2RX7NTRK1CSF1RNTRK2 | |
| SCHEMBL4430291 | 0.89 | P2RX7 (0.41) | P2RX7 | |
| SCHEMBL4434565 | 0.89 | P2RX7 (0.41) | P2RX7 | |
| SCHEMBL4429693 | 0.88 | P2RX7 (0.45) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |