Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4156 | 0.82 | NPC1 (0.48) | NPC1RAB9AKMT2AHTR1ALMNA | |
| SCHEMBL1200623 | 0.82 | NPC1 (0.48) | NPC1RAB9AKMT2AHTR1ALMNA | |
| SCHEMBL522925 | 0.82 | NPC1 (0.48) | NPC1RAB9AKMT2AHTR1ALMNA | |
| Hydrochloric Acid SCHEMBL27710967 | 0.81 | NPC1 (0.47) | NPC1RAB9AKMT2AHTR1ALMNA | |
| SCHEMBL4621986 | 0.81 | NPC1 (0.47) | NPC1RAB9AKMT2AHTR1ALMNA | |
| SCHEMBL12719830 | 0.81 | NPC1 (0.47) | NPC1RAB9AKMT2AHTR1ALMNA | |
| Hydrochloric Acid SCHEMBL27899374 | 0.81 | NPC1 (0.47) | NPC1RAB9AKMT2AHTR1ALMNA | |
| SCHEMBL12719842 | 0.81 | NPC1 (0.47) | NPC1RAB9AKMT2AHTR1ALMNA | |
| SCHEMBL4619913 | 0.81 | NPC1 (0.47) | NPC1RAB9AKMT2AHTR1ALMNA | |
| SCHEMBL4621336 | 0.81 | NPC1 (0.47) | NPC1RAB9AKMT2AHTR1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125772-B1 | A PROCESS FOR THE PREPARATION OF DULOXETIN AND NEW KEY INTERMEDIATES FOR USE THEREIN | RICHTER GEDEON NYRT (HU) | 2013-09-11 | — | — | EP | disclosed |
| EP-2125772-A1 | A PROCESS FOR THE PREPARATION OF DULOXETIN AND NEW KEY INTERMEDIATES FOR USE THEREIN | Richter Gedeon NYRT (HU) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008078124-A1 | A PROCESS FOR THE PREPARATION OF DULOXETIN AND NEW KEY INTERMEDIATES FOR USE THEREIN | RICHTER GEDEON NYRT. (HU) | 2008-07-03 | — | — | WO | disclosed |