Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | UTS2R | Q9UKP6 | 7/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR1F | P30939 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.48 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429895 | 0.92 | UTS2R (0.65) | POLBUTS2RMCHR1SIGMAR1KMT2A | |
| SCHEMBL2388998 | 0.91 | POLB (0.71) | POLBUTS2RMCHR1SIGMAR1KMT2A | |
| SCHEMBL4441069 | 0.90 | UTS2R (0.61) | POLBUTS2RMCHR1SIGMAR1KMT2A | |
| SCHEMBL2389969 | 0.84 | POLB (0.73) | POLBUTS2RMCHR1SIGMAR1KMT2A | |
| SCHEMBL2389088 | 0.83 | SIGMAR1 (0.69) | POLBUTS2RMCHR1SIGMAR1KMT2A | |
| SCHEMBL2387749 | 0.83 | UTS2R (0.70) | POLBUTS2RMCHR1SIGMAR1KMT2A | |
| SCHEMBL2389013 | 0.83 | UTS2R (0.71) | UTS2RMCHR1SIGMAR1KMT2AMEN1 | |
| SCHEMBL4430440 | 0.82 | DRD4 (0.59) | POLBUTS2RMCHR1SIGMAR1KMT2A | |
| SCHEMBL2387819 | 0.81 | SIGMAR1 (0.63) | POLBUTS2RMCHR1SIGMAR1KMT2A | |
| SCHEMBL2391006 | 0.81 | POLB (0.74) | POLBUTS2RMCHR1SIGMAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079694-A1 | N-SUBSTITUTED-HETEROCYCLOALKYLOXYBENZAMIDE COMPOUNDS AND METHODS OF USE | Rigel Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | claimed |
| WO-2008083124-A1 | N-SUBSTITUTED-HETEROCYCLOALKYLOXYBENZAMIDE COMPOUNDS AND METHODS OF USE | RIGEL PHARMACEUTICALS, INC. (US) | 2008-07-10 | — | — | WO | claimed |