Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 5/20 | 0.54 |
| ▸ | MAOB | P27338 | 3/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 3/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4425860 | 0.84 | MAOB (0.58) | NR4A2PPARGMAOBMAOAPPARA | |
| SCHEMBL21991803 | 0.80 | PPARA (0.73) | NR4A2PPARGMAOBMAOAPPARA | |
| SCHEMBL11734207 | 0.80 | PPARA (0.73) | NR4A2PPARGMAOBMAOAPPARA | |
| SCHEMBL11601217 | 0.80 | PPARG (0.57) | NR4A2PPARGMAOBMAOAPPARA | |
| SCHEMBL28510234 | 0.77 | MAOB (0.57) | NR4A2MAOBMAOAPARP10 | |
| SCHEMBL21991296 | 0.77 | NR4A2 (0.58) | NR4A2PPARGMAOBMAOAPPARA | |
| SCHEMBL197223 | 0.77 | LMNA (0.67) | NR4A2MAOBMAOAMRGPRX4BCHE | |
| SCHEMBL5389836 | 0.77 | PPARG (0.50) | NR4A2PPARGMAOBMAOAPPARA | |
| SCHEMBL5208740 | 0.76 | PPARA (0.62) | NR4A2PPARGMAOBMAOAPPARA | |
| SCHEMBL27309675 | 0.76 | PARP10 (0.57) | NR4A2PPARGMAOBMAOAPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761480-B1 | MAO-B INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-02-18 | — | — | EP | disclosed |