Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.48 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31144295 | 0.91 | TDP1 (0.64) | TDP1HTTAMY1ASMN1; SMN2LMNA | |
| SCHEMBL145997 | 0.91 | TDP1 (0.64) | TDP1HTTAMY1ASMN1; SMN2LMNA | |
| SCHEMBL144190 | 0.85 | ALDH1A1 (0.62) | TDP1SMN1; SMN2LMNAALDH1A1TP53 | |
| Bromide SCHEMBL8457695 | 0.84 | ALDH1A1 (0.60) | TDP1SMN1; SMN2ALDH1A1TP53HPGD | |
| SCHEMBL31493924 | 0.80 | HTT (0.66) | TDP1HTTKCNMA1SMN1; SMN2LMNA | |
| SCHEMBL443353 | 0.80 | TDP1 (0.64) | TDP1HTTKCNMA1SMN1; SMN2LMNA | |
| SCHEMBL31375357 | 0.80 | TDP1 (0.64) | TDP1HTTKCNMA1SMN1; SMN2LMNA | |
| SCHEMBL221924 | 0.80 | HTT (0.66) | TDP1HTTKCNMA1SMN1; SMN2LMNA | |
| SCHEMBL31463557 | 0.80 | TDP1 (0.50) | TDP1HTTAMY1ASMN1; SMN2LMNA | |
| SCHEMBL1531372 | 0.79 | HTT (0.64) | TDP1HTTKCNMA1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1755394-A4 | CANCER TREATMENT METHOD | SMITHKLINE BEECHAM CORP (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1755394-A2 | CANCER TREATMENT METHOD | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005105094-A2 | CANCER TREATMENT METHOD | SMITHKLINE BEECHAM CORPORATION (US) | 2005-11-10 | — | — | WO | disclosed |